Women’s Vascular Health
Estrogen and progesterone can work independently, together, and antagonistically on the endothelium – depending on their form and levels in the body. Current birth control and hormone therapy treatments utilize varied combinations of both natural and synthetic estrogens and progestogens. Despite widespread use of birth control and hormone therapy, the effects of these exogenous hormones on vascular regulation are not fully understood. Physiological maturity (pre-menopausal, post-menopausal) and underlying health conditions (such as insulin resistance, diabetes, hypertension, or obesity) can impact the vascular responses to estrogen and progesterone. Dr. Minson’s research team is currently investigating the independent and combined roles of estrogen and progesterone in women with Polycystic Ovary Syndrome, studying both overweight and lean populations. His team also investigates how the sympathetic nervous system contributes to vascular function and health in women, including how an increased sympathetic overdrive could lead to deleterious effects on cardiovascular and endocrine health.
We are currently recruiting subjects with PCOS for long-term heat therapy studies (see “Passive Heat Therapy” tab under the “Projects” pull-down) and we will be recruiting subjects with PCOS for other studies in the near future, so please stay tuned!